Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8243
Gene Symbol: SMC1A
SMC1A 		0.300 Biomarker disease GENOMICS_ENGLAND After prioritization and network analysis we found recurrent deleterious mutations in 8 individual genes (STAG2, U2AF1, SMC1A, USP9X, IKZF1, LYN, MYCBP2 and PTPN11) with a strong potential of being involved in APL pathogenesis. 26886259 2016
Entrez Id: 6354
Gene Symbol: CCL7
CCL7 		0.200 Biomarker disease RGD Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome. 19828696 2009
Entrez Id: 5914
Gene Symbol: RARA
RARA 		0.700 FusionGene disease ORPHANET "Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Français de Cytogénétique Hématologique, Groupe de Français d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action ""Molecular Cytogenetic Diagnosis in Haematological Malignancies""." 10942371 2000
Entrez Id: 4869
Gene Symbol: NPM1
NPM1 		0.700 FusionGene disease ORPHANET
Entrez Id: 4926
Gene Symbol: NUMA1
NUMA1 		0.620 FusionGene disease ORPHANET Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia. 9288109 1997
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16 		0.600 FusionGene disease ORPHANET Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia. 8387545 1993
Entrez Id: 5371
Gene Symbol: PML
PML 		0.600 FusionGene disease ORPHANET "Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Français de Cytogénétique Hématologique, Groupe de Français d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action ""Molecular Cytogenetic Diagnosis in Haematological Malignancies""." 10942371 2000
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16 		0.600 FusionGene disease ORPHANET "Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Français de Cytogénétique Hématologique, Groupe de Français d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action ""Molecular Cytogenetic Diagnosis in Haematological Malignancies""." 10942371 2000
Entrez Id: 6777
Gene Symbol: STAT5B
STAT5B 		0.570 FusionGene disease ORPHANET Clinical characteristics of APL with STAT5B-RARA are also discussed. 18221386 2008
Entrez Id: 359948
Gene Symbol: IRF2BP2
IRF2BP2 		0.530 FusionGene disease ORPHANET This is the first report showing involvement of IRF2BP2 in APL, and it expands the list of novel RARA partners identified in APL. 25583766 2015
Entrez Id: 359948
Gene Symbol: IRF2BP2
IRF2BP2 		0.530 FusionGene disease ORPHANET This is the second report of IRF2BP2 involvement in APL, and we describe various breakpoints for the IRF2BP2-RARA fusion gene. 27193600 2016
Entrez Id: 5573
Gene Symbol: PRKAR1A
PRKAR1A 		0.520 FusionGene disease ORPHANET This novel PRKAR1A-RARA gene rearrangement is the fifth variant APL in which the RARA partner gene has been identified and the second known rearrangement of PRKAR1A in a malignant disease. 17712046 2007
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.330 FusionGene disease ORPHANET Identification of novel recurrent STAT3-RARA fusions in acute promyelocytic leukemia lacking t(15;17)(q22;q12)/PML-RARA. 29237593 2018
Entrez Id: 79718
Gene Symbol: TBL1XR1
TBL1XR1 		0.330 FusionGene disease ORPHANET In this study, we identified a novel RARα fusion gene, TBLR1-RARα (GenBank KF589333), in a rare case of APL with a t(3;17)(q26;q21),t(7;17)(q11.2;q21) complex chromosomal rearrangement. 24782508 2014
Entrez Id: 54880
Gene Symbol: BCOR
BCOR 		0.320 FusionGene disease ORPHANET It should be noted that there was no intact BCOR found in the 45,-Y,t(X;17)(p11;q12) APL cells because they featured only a rearranged X chromosome. 20807888 2010
Entrez Id: 54880
Gene Symbol: BCOR
BCOR 		0.320 FusionGene disease ORPHANET Successful treatment of acute promyelocytic leukemia with a t(X;17)(p11.4;q21) and BCOR-RARA fusion gene. 25790901 2015
Entrez Id: 64859
Gene Symbol: NABP1
NABP1 		0.310 FusionGene disease ORPHANET OBFC2A/RARA: a novel fusion gene in variant acute promyelocytic leukemia. 23287866 2013
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1 		0.300 FusionGene disease ORPHANET The seventh pathogenic fusion gene FIP1L1-RARA was isolated from a t(4;17)-positive acute promyelocytic leukemia. 18603554 2008
Entrez Id: 5914
Gene Symbol: RARA
RARA 		0.700 Biomarker disease HPO
Entrez Id: 4926
Gene Symbol: NUMA1
NUMA1 		0.620 Biomarker disease HPO
Entrez Id: 6609
Gene Symbol: SMPD1
SMPD1 		0.100 Biomarker disease HPO
Entrez Id: 5914
Gene Symbol: RARA
RARA 		0.700 Biomarker disease LHGDN Frequent antibody production against RARalpha in both APL mice and patients. 16728697 2006
Entrez Id: 5914
Gene Symbol: RARA
RARA 		0.700 AlteredExpression disease LHGDN Topoisomerase IIbeta negatively modulates retinoic acid receptor alpha function: a novel mechanism of retinoic acid resistance. 18212063 2008
Entrez Id: 5914
Gene Symbol: RARA
RARA 		0.700 Biomarker disease LHGDN Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways. 11929748 2002
Entrez Id: 5914
Gene Symbol: RARA
RARA 		0.700 Biomarker disease LHGDN UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. 11891284 2002